The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors
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چکیده
منابع مشابه
Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.
Previous studies have shown that the intestinal peristaltic reflex initiated by mucosal stimulation is mediated by release of 5-hydroxytryptamine (HT) from enterochromaffin cells; 5-HT acts via 5-HT4 receptors in rat and human, and via both 5-HT4 and 5-HT3 receptors in guinea pig to activate intramural sensory neurons that release calcitonin gene-related peptide. In this study, selective agonis...
متن کاملDistribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon
BACKGROUND/AIMS Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-as...
متن کامل5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder.
The function of 5-hydroxytryptamine (5-HT) receptors, especially the 5-HT4 receptor, in the urinary bladder were examined in preparations isolated from the guinea pig by in vitro receptor autoradiography and determinations of mechanical activity and acetylcholine (ACh) release. Specific [125I]SB207710 binding sites were detected evenly throughout the urinary bladder. 5-HT (3 x 10(-8)-10(-4) M) ...
متن کامل5-HT3 receptors and emesis
Nausea and vomiting. Nausea and vomiting is a major problem which occurs during and after the treatment with certain drugs like anesthetics, opioidanalgesics or cytostatics. Postoperative nausea and vomiting (PONV) is called the “big” little problem. As a consequence, the choice of the anesthetic drug(s) plays a role in preventing PONV [Apfel et al., Anesthesiology, 1999; Eberhart et al., Eur J...
متن کاملTemporal regulation of agonist efficacy at 5-hydroxytryptamine (5-HT)1A and 5-HT 1B receptors.
Coactivation of purinergic (P 2Y) receptors reduces agonist efficacy at serotonin 1B (5-HT 1B), but not 5-HT 1A receptors. Herein, we report that pretreatment for 5 min with the P 2Y receptor agonist ATP reduced agonist responsiveness at the 5-HT 1A, but not at the 5-HT 1B, receptor. The effect of ATP pretreatment on the 5-HT 1A receptor response rapidly reversed within a 10 min time frame betw...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb12812.x